Zakrytoe Aktsionernoe Obshchestvo "Masterlek" (RU) Russian patent .pdf)
MEDICINAL AGENT FOR TREATMENT OF ATYPICAL PNEUMONIA
Glushkov R.G., Maksimov V.A., Martíjanov V.A., Khamitov R.A., Shuster A.M.
SUBSTANCE: invention proposes an agent for
treatment and prophylaxis of infection caused by coronaviruses, in particular, for treatment of
atypical pneumonia (SARS), and pharmaceutical composition of indicated designation based on
thereof. Agent represents 1-methyl-2-phenylthiomethyl-3-carbethoxy
-4-dimethylaminomethyl-5-oxybromoindole or 1-methyl-
hydrochloride (arbidol) known early as an immunomodulator and preparation used against
influenza viruses. Invention provides reducing accumulation of coronaviruses (on example with
TOPS virus) in lung.
EFFECT: valuable medicinal properties of agent.
VIROLOGICA SINICA Vol.20 No.2 April 2005 - Full text not available at this time
Inhibitory Effect of Arbidol Hydrochloride on Coxsackievirus B3 Group in vitro
XIONG Hai-rong, YANG Zhan-qiu, LIU Yin-juan, et al
Arbidol hydrochloride Coxsackievirus group B3 Antiviral effect
Abstract: To study the antiviral activity of Arbidol hydrochloride on Coxsackievirus
Group B_3 (CVB_3), the antiviral effect of Arbidol hydrochloride were evaluated with virus inhibitory rates by
MTT assay and 50% tissue culture infection dose (TCID_(50)) of the supernatant. The results showed that the
viral inhibitory rates were up to 75.48%,45.68%,28.90% and 48.27% respectively in interrupting viral biosynthesis
group, directly killing virus group, interfering in viral absorption and penetration groups(2h and 8h). In interrupting
viral biosynthesis group,Arbidol hydrochloride could significantly inhibit cytopathic effect (CPE) of CVB_3-infected HEp-2 cells,
increase survival rates of CVB_3-infected cells in dose dependent manner and decrease viral titers of the supernatant. It
indicates that Arbidol hydrochloride has antiviral effect against Coxsackievirus group B3 (CVB_3).
Original Chinese Document .pdf
17th of September, Ufa, "Bashinform", Elena Makuschina - Full text not available at this time
Russian preparation "Arbidol" proved effective against SARS.
Tests of effectiveness of Russian preparation "Arbidol" with respect to pathogen of SARS have been finished, "MEDNOVOSTI" reports.
This preparation was created by joint efforts of Russian chemical-pharmaceutical institute, institute of medical radiology of Russian Academy of medical sciences
in Obninsk and Leningrad institute of epidemiology and microbiology of Paster. "Arbidol" is successfully used for treatment and prophylactics of flue and acute
respiratory diseases for already several years. Virology Center of scientific-investigational institute of microbiology of RF has conducted investigations of
effectiveness of "Arbidol" with respect to pathogen of SARS.
For evaluation of effectiveness of this preparation they used hamsters from Syria, infected by SARS. When using "Arbidol" in a definite doze reproduction
of the virus was suppressed by 99,2% already for the second day after infecting and practically completely for the 10th day.
Tests of "Arbidol" were also organized in the laboratory of World Center of World Health Organization in London. Specialists say
anti-virus action of "Arbidol" was proved according to severest international rules. It was also proved this preparation was active
against the virus of bird flue.