Arbidol
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Pre 1990

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Arbidol

Arbidol research index:

Journal of Wuhan University (Medical Edition) 2006 Vol.27 No.1 P.69-71 - Full text not available at this time

Arbidol hydrochloride against respiratory syncytial virus mechanism

Jing Lingli Li Shi Bridge Institute, Xiao Hong

Abstract : Objective : Arbidol hydrochloride clear anti-absorption respiratory syncytial virus (RSV) Long lines of the anti-viral activity and its mechanism. Methods : Through cytopathic effect (CPE), thiazole (MTT) assay for measuring cell activity. To evaluate the role of Arbidol anti-RSV. Results : Arbidol half of the concentration of hydrochloric acid toxicity (TD50) 85.39 L, When the drug concentration of 25 L, anti-viral drugs biosynthesis Group, a direct role in drug group. Anti-drug adsorption 4 h, 8 h adsorption antiviral drugs inhibit the virus could reach 81.61% respectively. 79.57%. 78.60%.4 the drug group were 40.39% and 50% effective concentration (ED50) 11.52. 8.74,25.36 L and 10.40. Conclusion : Arbidol hydrochloric acid can inhibit the in vitro effect of the CPE RSV, virus inhibition rate increased with increasing concentration of the drug, through various channels, Arbidol hydrochloride play the role of anti-RSV.

Keywords : Arbidol hydrochloride; Respiratory syncytial virus; Antivirus; Heidelberg School Official Cites Use code : A; 1671-8852 (2006) 01-0069-03

Anti-viral Activity of Arbidol Hydrochloride Against Respiratory Syncytial Virus in Vitro


Journal of Wuhan University (Medical Edition) "Volume 1, 27 Page 3 : - Full text not available at this time

Antiviral Effect of Arbidol Hydrochloride on Adenovirus Type 7 in Vitro

SHI Bridge (Li-Qiao Shi); Virology (Zhan-Qiu Yang); Jing (Jing He); Liu Yuanyuan (Yuan-Yuan Liu); Xiao Hong (Xiao Hong)

Objective : To determine the antiviral Arbidol vitro adenovirus type 7 (ADV-7) mode. Method : To investigate the cytopathic effect (CPE), thiazole (MTT) assay for measuring cell activity. 3 virus titration methods from the biosynthesis of anti-viral drugs, Anti-virus and anti-virus drugs directly drug adsorption Arbidol Detection of the three modes. Results : Study of ADV-7 Arbidol no direct destruction, but also can prevent the absorption and penetration ADV-7. CPE is typical of the treatment group, but significantly inhibited ADV-7 Arbidol hydrochloric acid biosynthesis, half of cell toxicity concentration (CC50) 85.37mg/L. ADV-7 half of the effective concentration (IC50) 15.39mg/L. the therapeutic index (TI) of 5.55, and with the increasing concentration of the drug, the virus-induced CPE effect has been on the wane. The virus titer in culture medium gradually decreased and the virus inhibition rates were significantly increased. Conclusion : In vitro Arbidol hydrochloric acid biosynthesis by inhibiting the virus and anti ADV-7 play the role The specific mechanism should be further examined.

Objective : To investigate the antiviral activity of Arbidol hydrochloride against adenovirus type 7 (ADV-7) in vitro. Methods : The antiviral effect of Arbidol infected cells was studied by assaying for protection from cytopathic effect (CPE) adopting MTT colorimetric assay for viral inhibitory rate and viral titers. Results : Arbidol displayed antiviral activity against ADV-7 when added after infection with 50% cytotoxic concentration (CC50) and 50% inhibitory concentration (IC50) of 85.37 and 15.39 L L, resulting in a treatment index (TI) of 5.55. With the in crease of the drug dose. the degree of CPE and viral titers decreased correspondingly. whereas viral inhibition rate increased. As typical CPE were observed at all concentrations. Arbidol showed no abilities of directly-killing ADV-7 and had no effect on viral absorption and penetration. Conclusion : These results indicate that Arbidol suppresses the late stage of viral cycle. Arbidol should be considered further as a muli-factorial and prospective antiviral substance.

Keywords Arbidol hydrochloride, adenovirus type 7, anti-viral drugs; Arbidol Hydrochloride. Adenovirus, Antiviral Effect



Journal of Wuhan University (Medical Edition) MEDICAL JOURNAL OF WUHAN UNIVERSITY 2006 Vol.27 No.1 P.66-68 - Full text not available at this time

Arbidol hydrochloride Experimental study of anti - adenovirus type 7

Li Shi Jing bridge Virology Institute, Xiao Hong

Abstract : Objective : Arbidol hydrochloride clear antiviral drug resistance in vitro adenovirus type 7 (ADV-7) mode. Methods : primarily through observation of cytopathic effect (CPE), thiazole (MTT) assay for measuring cell activity. 3 virus titration methods from the biosynthesis of anti-viral drugs, Anti-virus and anti-virus drugs directly drug adsorption Arbidol Detection of the three modes. Results : Study of ADV-7 Arbidol no direct killing effect ADV-7 can prevent the absorption and penetration. CPE is typical of the treatment group, but significantly inhibited ADV-7 Arbidol hydrochloric acid biosynthesis, half of cell toxicity concentration (CC50) 85.37 L, ADV-7 half of the effective concentration (IC50) to 15.39 L, the therapeutic index (TI) of 5.55, and with the increasing concentration of the drug, the virus-induced CPE effect has been on the wane. The virus titer in culture medium gradually decreased and the virus inhibition rates were significantly increased. Conclusion : Arbidol hydrochloric acid biosynthesis in vitro by inhibiting the virus and anti ADV-7 play the role The specific mechanism should be further examined.


Huaxi Pharmaceutical Journal, 2004 06 period Full text not available at this time

Antiviral activity of Arbidol hydrochloride against respiratory syncytial virus - Arbidol hydrochloride against respiratory syncytial virus in experimental study

Sun, Virology, Xiao Hong, Hung Italy relations, Wen Li, Zhao Liu

Objective Arbidol hydrochloride. amantadine and ribavirin in cell culture Hep-2 inhibitor of respiratory syncytial virus role. Methods CPE inhibition assay. Determination of three kinds of drugs on the respiratory syncytial virus-induced cytopathic effect of Hep-2 inhibition. results of the three-drug anti-RSV IC50 followed Arbidol hydrochloride (38.2 g ml). Amantadine hydrochloride (68.0 g ml) and ribavirin (80.3 g ml). TI to 5.2,2.7,4.7, Arbidol hydrochloride which showed a strong inhibition of respiratory syncytial virus effect. Anti-respiratory syncytial virus in vitro conclusion of the three experimental drugs. Arbidol hydrochloride should be the first choice.


Vopr Virusol. 2002 Mar-Apr;47(2):42-5. - Full text not available at this time

Study of the effect of antiviral drugs on the reproduction of the respiratory syncytial virus by enzyme immunoassay

Leneva IA, Sokolova MV, Fediakina IT, Khristova ML, Fadeeva NI, Gus'kova TA.

A test system based on EIA was developed for evaluating the efficiency of drugs active towards the respiratory syncytial virus (RSV) in cell culture. Virasole and its structural analog ribamedii active towards RSV infection and arbidol whose activity in RSV infection is unknown were tested. Like virasole and ribamedil, arbidol inhibited the expression of RSV antigens, the inhibitory effect increasing with the drug concentration and decreased with increase of the multiplicity of virus infection. MIC50 for arbidol, virasole, and ribamedil were 10, 5, and 6 micrograms/ml, respectively. These data prompt clinical trials of arbidol in RSV infection.

PMID: 12046469 [PubMed - indexed for MEDLINE]


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