Vestn Ross Akad Med Nauk. 1999;(3):36-40. - Full text not available at this time
Mechanisms of arbidole's immunomodulating action
Glushkov RG, Gus'kova TA, Krylova LIu, Nikolaeva IS.
The immunomodulating activity of arbidole was studied in cultured cells,
animals, and human beings. Arbidole was shown to have effects on nonspecific defense factors, on
its capacity to induce interferon and activate phagocytes in particular. Arbidole-treated patients
with lower baseline immunity showed improvement in immunological parameters (in the counts of CD4
and CD8 lymphocytes, B lymphocytes, in the levels of serum immunoglobulins). Arbidol produces a
high preventive and therapeutical effects in influenza A and B and other acute respiratory viral
infections, prevents postinfluenza complications, reduces the incidence of exacerbations of chronic
diseases in postinfluenza patients. In influenza, the therapeutical efficiency of the drug appears
as decreases in intoxication, the severity of catarrhal syndrome, shorter fever and disease in
general. Arbidole is beneficial for patients with second immunodeficiency, in those with recurrent
herpes infection or chronic bronchitis. After arbidole treatment regimen, postoperative immunological
parameters became normal in cardiac surgical patients, which suggests that the drug should be used
in cardiac surgical care. The agent showed no side effects in any case.
PMID: 10222830 [PubMed - indexed for MEDLINE]
Radiats Biol Radioecol. 1994 Jul-Oct;34(4-5):482-8. - Full text not available at this time
Immunopharmacological analysis of secondary postradiation immunodeficiency
Ivanov AA, Deshevoi IuB, Karpova NA, Lebedev VG, Leonenko IV, Stavrakova NM,
Tazulakhova EB, Ulanova AM, Khaustova LI, Shal'nova GA, et al.
A model for secondary postradiation immunodeficiency of mice has been used to
compare immunocorrective activities of some new immunomodulators (arbidol, cagocel, myelopid,
proleukinferon and fragmine) administered at late times (2-3 months) after exposure to a nonlethal
radiation dose (4.0 Gy). The highest immunocorrective effect has been shown with fragmine and
PMID: 7951873 [PubMed - indexed for MEDLINE]
Biull Eksp Biol Med. 1994 Jul;118(7):80-1. - Full text not available at this time
Antimetastatic effects of the new antiviral agent arbidol
Fedorovskaia EO, Tsyshkova NG, Poverennyi AM, Tsyb AF.
PMID: 7919283 [PubMed - indexed for MEDLINE]